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It’s an agonist for serotonin receptors, which helps explain why it makes you feel good and reduces anxiety.9 It also has a role in preventing the breakdown of anandamide, a lipid mediator that acts on CB1 and CB2 cannabinoid receptors to make them more sensitive to endogenous cannabinoids.10 And since endocannabinoid signaling is part of the neuromodulatory system, some researchers point out that increased anandamide can fight anxiety.11 With so many potential mechanisms of action involved, some overlapping to enhance CBD’s effects, mapping out its exact activity in fighting anxiety remains elusive