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In 1991, for instance, a double-blind trial of topical capsaicin found that the intervention group experienced “significantly more pain relief” than their placebo counterparts, with average pain score reductions of 57% in rheumatoid arthritis and 33% in osteoarthritis.16 Menthol Menthol is a mint compound commonly used in topical analgesics, including over-the-counter products like Biofreeze and Icy Hot